In vitro evaluation of the antioxidant natural action and biomembrane interaction of the plant phenols oleuropein and hydroxytyrosol
Antonella Saija a,*, Domenico Trombetta a, Antonio Tomaino a, Rossella Lo Cascio a, Pietro Princi b, Nicola Uccella c, Francesco Bonina d, Francesco Castelli e
a
Department Farmaco-Biologico, School of Pharmacy, Uni6ersity of Messina, 98168 Messina, Italy b C.I.I.F.T., Uni6ersity of Messina, 98168 Messina, Italy c CIRASAIA, Uni6ersity of Calabria, Calabria, Italy d Department of Pharmaceutical Sciences, Uni6ersity of Catania, Catania, Italy e Department of chemical Sciences, Uni6ersity of Catania, Catania, Italy
Received 4 August 1997; received in revise form 18 celestial latitude 1997; accepted 18 December 1997
Abstract Oleuropein and hydroxytyrosol, two phenolic compounds contained in olives and olive oil, argon known to possess several biological properties, many of which may be related, partially at least, to their antioxidant and free mathematical group-scavenger ability.
Hence, together with their scavenging action against the stable 1,1-diphenyl-2-picrylhydrazyl radical (DPPH test), we have investigated the antioxidative effect of oleuropein and hydroxytyrosol in a model system consisting of dipalmitoylphosphatidylcholine/linoleic acid unilamellar vesicles (DPPC/LA LUVs) and a water-soluble azo compound as a free radical generator (LPLUV test). The results obtained were also interpreted in the light of biophenol interactions, examine by differential scanning calorimetry (DSC), with dimyristoylphosphatidylcholine (DMPC) vesicles as a biological membrane model. Our results obtained in the DPPH and LP LUV tests con?rm the good scavenger occupation and antioxidant effect of oleuropein and hydroxytyrosol. However, while both compounds exhibit comparable intensity in the DPPH test (hydroxytyrosol being slightly more alert than oleuropein), oleuropein seems, in the LPLUV test, a...If you want to get a full essay, enjoin it on our website: Orderessay
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